Protein
BRCA1-A complex subunit Abraxas 1
Organism
Xenopus tropicalis
Function
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of brca1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (By similarity).
Similarity
Belongs to the FAM175 family. Abraxas subfamily.
Sequence
MEGESTTAVMSGFVFGALTFHHLNSGSDTEGFLLGDVVGEAKNSITDSQMDDVEVLYTIDIQKHVPCYKLSRFYNVLGDLNIPELKKLLADQKKSQNVIGWYKFRHNTEQIMTFRERLLHKNLQEHLSNSGLVFLLLTSNPATETKSTHRLEYALHKPQDGFFHKVPLVISNLGMSDQQGYKTLCGSCVSVGLNTTIKKHRLEFFNEDGALAEVNRISNMYTTLQDELKKTCSQLVESEHSVEQLLEAINELKKQIAEKKKLNEETGNKVSEAPEENVLLCEALRKFFPQSTLLQSCRLSLGGRQIPHSCTASHNISDVNELTLMVKQYDIPEAHTRQAGKRKACSKQLGRTLTKKSRLLQLQKQHSQNGDSEGSDSERPLCNSGTETDGDILESLHMDVSRSKSPIF