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ABRAXAS1

Gene
ABRAXAS1
Protein
BRCA1-A complex subunit Abraxas 1
Organism
Bos taurus
Length
410 amino acids
Function
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Similarity
Belongs to the FAM175 family. Abraxas subfamily.
Mass
46.184 kDa
Sequence
MEGESTTAVLSGFVLGALAFQHLNTDSDTEGFLLGEVKGEAKNSITDSQMDDVEVIYTIDIQKYISCYQLFSFYNSSGEVNEQALKKILSNVKKDVVGWYKLRRHSDQIMTFRERLLHRNLQQHLSSQELVFLLLTPSIITESCSTHRLEHALYKPQKGLFHRIPLVVANLGMSEQLGYKTTSGSCTSAGFSRAVKTHSSEFFKEDGSLKEVQKINEMYTSLQDELKSICEKVEHSERAVEKLLNDVNRLKGEIKKRKQAQMQATREKNVQKDPQENILLCQALRTFFPDCELLHSCVISLKNRRISGSSCTTTHPLSGVDNLTLMVEYTDFPEASPARSALLVTKRKASDTDDGWQFKKSRLGGIQNRPSKTDTNSSNQEQASTVSSPETDEEIERMKGSGEYPQSPTF

Gene
ABRAXAS1
Protein
BRCA1-A complex subunit Abraxas 1
Organism
Homo sapiens
Length
409 amino acids
Function
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Similarity
Belongs to the FAM175 family. Abraxas subfamily.
Mass
46.663 kDa
Sequence
MEGESTSAVLSGFVLGALAFQHLNTDSDTEGFLLGEVKGEAKNSITDSQMDDVEVVYTIDIQKYIPCYQLFSFYNSSGEVNEQALKKILSNVKKNVVGWYKFRRHSDQIMTFRERLLHKNLQEHFSNQDLVFLLLTPSIITESCSTHRLEHSLYKPQKGLFHRVPLVVANLGMSEQLGYKTVSGSCMSTGFSRAVQTHSSKFFEEDGSLKEVHKINEMYASLQEELKSICKKVEDSEQAVDKLVKDVNRLKREIEKRRGAQIQAAREKNIQKDPQENIFLCQALRTFFPNSEFLHSCVMSLKNRHVSKSSCNYNHHLDVVDNLTLMVEHTDIPEASPASTPQIIKHKALDLDDRWQFKRSRLLDTQDKRSKADTGSSNQDKASKMSSPETDEEIEKMKGFGEYSRSPTF

Gene
abraxas1
Protein
BRCA1-A complex subunit Abraxas 1
Organism
Xenopus laevis
Length
408 amino acids
Function
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of brca1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (By similarity).
Similarity
Belongs to the FAM175 family. Abraxas subfamily.
Mass
45.823 kDa
Sequence
MEGESTTAVISGFVFGALTFHHLNSGSDTEGFLLGDVMGEAKNSITDSQMDDVEVLYTIDIQKHVPCYQLSRFYNALGDLNIPELKKLLAGQKKSQNVIGWYKFRHNTEQIMTFRERLLHKNLQEHFSNSGLVFLLLTSNPATETKSTHRLEYALHKPQDGFFHKVPLVISNLGMSDQQGYKTLCGSCVSVGLNTAIKKHRLEFFNEDGALAEVNRISDMHMTLQEELKKTCSQLVESENSVEQLLEAVNDLKKQIAEKKLLMEEKGNKVSEDTEENVLLCEAFRRFFPQSALLQSCRLSLGGRQIPHSCSVSHNSSDVNELTLMVKQYDFPEAHRRQAGKRKAHSKQLGKTSTKKSRLPPFQRPQSDNSDSESSDSEKLLCTSGTETDGDIVQSLNVEVSRSKSPTF

Gene
abraxas1
Protein
BRCA1-A complex subunit Abraxas 1
Organism
Xenopus tropicalis
Length
408 amino acids
Function
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of brca1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (By similarity).
Similarity
Belongs to the FAM175 family. Abraxas subfamily.
Mass
45.828 kDa
Sequence
MEGESTTAVMSGFVFGALTFHHLNSGSDTEGFLLGDVVGEAKNSITDSQMDDVEVLYTIDIQKHVPCYKLSRFYNVLGDLNIPELKKLLADQKKSQNVIGWYKFRHNTEQIMTFRERLLHKNLQEHLSNSGLVFLLLTSNPATETKSTHRLEYALHKPQDGFFHKVPLVISNLGMSDQQGYKTLCGSCVSVGLNTTIKKHRLEFFNEDGALAEVNRISNMYTTLQDELKKTCSQLVESEHSVEQLLEAINELKKQIAEKKKLNEETGNKVSEAPEENVLLCEALRKFFPQSTLLQSCRLSLGGRQIPHSCTASHNISDVNELTLMVKQYDIPEAHTRQAGKRKACSKQLGRTLTKKSRLLQLQKQHSQNGDSEGSDSERPLCNSGTETDGDILESLHMDVSRSKSPIF

Gene
Abraxas1
Protein
BRCA1-A complex subunit Abraxas 1
Organism
Mus musculus
Length
407 amino acids
Function
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Similarity
Belongs to the FAM175 family. Abraxas subfamily.
Mass
46.039 kDa
Sequence
MEGESTLGVLSGFVLGALTFHHLNTDSDTEGFLLGEMKGEAKNSITDSQMDNVKVVYTIDIQKYIPCYRLFSFYNSLGEVNEHALKKVLSNVRKTVVGWYKFRRHSDQIMTFREQLLHRNLQTHLSSPELVFLLLTPSITTESCSTHCLEHALYKPQRGLFHRVPLVVTNLGMSDQLGYKTEPASCTSTVFSRAVRTHSSQFFNEDGSLKEVHKINEMYAAVQEELKSICQKVEQSEREVEKLLMDVNQLKEVRRTQQARATGAGEKNVQRNPQENILLCQALRTFFPESEVLHSCVISLKNRHISPSGCNVNHHVDVVDQLTLMVEYVYSPEASPVPTAQLRKRKALDTHDQGSVKRPRLLETESRPSVAASRSRHQDKASSSSLDIDIEMGSPEDDADYPRSPTF

Gene
ABRAXAS1
Protein
BRCA1-A complex subunit Abraxas 1
Organism
Gallus gallus
Length
405 amino acids
Function
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Similarity
Belongs to the FAM175 family. Abraxas subfamily.
Mass
46.043 kDa
Sequence
MEGESTSALLSGFVFGALAFQHLSTDSDTEGFLLGDVKGEAKNSITDSQMDDVEVVYTIDIQKHIPCYQLFSFYNSAGELNEPALKKILSGRKKSVIGWYKFRRNTDQIMTFRERLLHKNLQSHLSNQGLVFLLLTSSVMTESCSTYRLEHALHRPQEGLFQKVPLVVTNLGMAEQQGYRTVSGSCASSGFVRAVKQHRSEFFYEDGSLQEVHKINEMYATLQEELKKMCSDVEVSERSVEKLLTEVSQLKEEINRKKQHKISSGGNKDQLEEPKENVLLCQALRTFFPSSDLQTCIVSFKGRISKNCCKIDHNINIMDKLTLMVEERDFTEAETKLVTKRKVRVTTTGPKSLKKLRSLQLDQELHQDEEDCNQETKLALSSAETDEEALENPKDTNEYSYSPTF

Gene
ABRAXAS1
Protein
BRCA1-A complex subunit Abraxas 1
Organism
Rattus norvegicus
Length
405 amino acids
Function
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Similarity
Belongs to the FAM175 family. Abraxas subfamily.
Mass
45.69 kDa
Sequence
MEGESTLGVLSGFVLGALTFQHLNTDSDTEGLLLGEMKGEAKNSITDSQMDSVKVVYTIDIQKYIPCYRLFSFYNSLGEVNEHALKKILSNVKKTVVGWYKFRRHSDQIMTFREQLLHRNLQTHLSSPELVFLLLTPSITTESCCTHCLEHGLYKPQSGLFHKVPLVVTNLGMSDQLGYKTESVSCTSTVFSRAVRTYSSQFFNEDGSLKEVRKINEMYAAIQEELKTICQKVEQSEREVEKLLMDVNRLKEVRKKQQAQAKGAGEKSQNHPQENILLCQALRTFFPESRVLHSCVISLKNRHISHSGCNTDHHLDVVDKLTLMVEYVYSPEASPAPAAPLSKRKALDTQDQWPAKRPRLLESESRPGPAFRGSHQDKASSSSLDIDTEVGSPEDDTDYPRSPTF

Gene
abraxas1
Protein
BRCA1-A complex subunit Abraxas 1
Organism
Salmo salar
Length
404 amino acids
Function
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of brca1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (By similarity).
Similarity
Belongs to the FAM175 family. Abraxas subfamily.
Mass
45.769 kDa
Sequence
MEDSNSYIRVSGFVLGSLMFQHLNSDSDVEGLILGETKAEERSNITDSQIDNIQFEHTINIQKHISCRKLNSFYNRIGEVNRDEIRHILSNYKEENVIGWYKQRRNTDQQITFREQVVHENLKRALSNHELIFLLLTPSEITTSGSTHKLEYAVYRSHGSQYCSVPVLVSNLGLLEEQDYWRLSASCSSVNYNHAVRKHRSKFFSSDGSLHEVDEINDMNNSLQGELKMACKKVEESERLVEKLLADVSDLRRMVNERKQELREISADGASTPAQPRENVLLCEVIKTLFPGASLLQTQALNFQGFPLPEFCCSTDHGIDIATTLPLILSHTLPKARKGRLGRGGGTSWRKCPLRESSEVPKRRKGMLEETDETLSVSGSETEEDLIPANRNGNNLDVSNSPVF

Gene
abraxas1
Protein
BRCA1-A complex subunit Abraxas 1
Organism
Danio rerio
Length
391 amino acids
Function
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of brca1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (By similarity).
Similarity
Belongs to the FAM175 family. Abraxas subfamily.
Mass
44.635 kDa
Sequence
MEEFNTTVRISGFVLSSLMFHHLNSDADVEGLILGESVGEENCRITDSQIDHIQFEHTLNIQKHIPCHKLHSFYSNVGDVSEQKIRQILSDYKEENVIGWYRQRRNTRQQMTFMEQVIHRNMRKILSNQELVFMLLTPSQGTASGSTHRLEFSAFIWHSSQYINIPISVSNLGNLEQQDYWRVSSTCPSLGQSQAVNQHRAKFFCSGDDLREVRNVSDMNDALLAEMQKVCVEVEKSERTVEKLQEDIAQLKEAIGKQKTHPEEHETPISACPEEPKENTLLCSALRTLFPSVPSLRTQTLTVHGFPVLQLCCNTDHNIDISTKLPQILENQHSRRKVTAPRLRKKCLVASFPQRLKRKRKTREVSESASESGSDTEIEMNGQSGSNSPVF