Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.

Belongs to the FAM175 family. Abraxas subfamily.

405 amino acids

MEGESTLGVLSGFVLGALTFQHLNTDSDTEGLLLGEMKGEAKNSITDSQMDSVKVVYTIDIQKYIPCYRLFSFYNSLGEVNEHALKKILSNVKKTVVGWYKFRRHSDQIMTFREQLLHRNLQTHLSSPELVFLLLTPSITTESCCTHCLEHGLYKPQSGLFHKVPLVVTNLGMSDQLGYKTESVSCTSTVFSRAVRTYSSQFFNEDGSLKEVRKINEMYAAIQEELKTICQKVEQSEREVEKLLMDVNRLKEVRKKQQAQAKGAGEKSQNHPQENILLCQALRTFFPESRVLHSCVISLKNRHISHSGCNTDHHLDVVDKLTLMVEYVYSPEASPAPAAPLSKRKALDTQDQWPAKRPRLLESESRPGPAFRGSHQDKASSSSLDIDTEVGSPEDDTDYPRSPTF

45.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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