Function
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
Similarity
Belongs to the PIH1 family. Kintoun subfamily.
Sequence
MSNVGDKFELSRDEFRNITQCLGNEEFRKLFAEYCQELKDPENRKQYEEELKLMEAERGYDVKFIKPLPGYVIKTVVDGKTKAFVNVCHCDLVGKPSSQCSTNKRGEKGLKWSIPYAQSQPRKDYDNKNVDCVVYDVVFHYDTLHLTKSNKNFRKLVTDTALDAVEGAFHVSLDRVNLKFPKLQYKGVAKMTVIRQKLKNFETRRKDGLIDTLYRASEQSKITHDNSADKENVNKQTFKSASQLEYTTPAYKLIHRKEVEYHELTGELDAKLDAAIPKELVLVIELPLLKSANQCTLNVTSSEVHLISDSPAKYKLEVKLPYTVLEKNGSAKFNTDETTLTVLLPVARNRRTLNDVTVSSNDQSMPDEMDQKPVERVKPLKEPQLVHSNANKKIIFPKFSANKMDNIFAFTLNVRNVDPSSIELQKGTDTVSCRFTNIGNGFFPCYYIFFLRFPNANITEVQHEEWDNNIILQVVLDHGLIDCYYAGTNENDLVQYSIMEDITDKINKFGKEIEDDSLCIAVSKNAIKQERKSSHLSIEIKTKDEIESDEGIDSALEGELKTDQSMQEDENPDEINTRTVEDDTKVAKENVKKVDQETAHEGKKSKKNQRRKNKKRSLSESCCDHLKVTINNDNPKPESGNEANSFEGTGSSSEATSKQRKARSVSESCPARDNNGVESDSVDNLSALIQFNHKYKGILKRSSLQRSISECSSIDEHYYLGTSVDGSSVAESVDHTNGELSESCRKTVRFNDAIKTKLFRSNTSILGQKKKNAKKNESKRRALTRRLSEGESTDNEDKDHQTTNEAPGSVVQRDTEHDSGISLDSDAAHPIEINADTEVQNQHQNDSTKPIEINRKVEKKFIASKNNNCNVKAQFIKSKRNDSSDIEFKSDMIFDIEM