Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.

Belongs to the PIH1 family. Kintoun subfamily.

898 amino acids

MSNVGDKFELSRDEFRNITQCLGNEEFRKLFAEYCQELKDPENRKQYEEELKLMEAERGYDVKFIKPLPGYVIKTVVDGKTKAFVNVCHCDLVGKPSSQCSTNKRGEKGLKWSIPYAQSQPRKDYDNKNVDCVVYDVVFHYDTLHLTKSNKNFRKLVTDTALDAVEGAFHVSLDRVNLKFPKLQYKGVAKMTVIRQKLKNFETRRKDGLIDTLYRASEQSKITHDNSADKENVNKQTFKSASQLEYTTPAYKLIHRKEVEYHELTGELDAKLDAAIPKELVLVIELPLLKSANQCTLNVTSSEVHLISDSPAKYKLEVKLPYTVLEKNGSAKFNTDETTLTVLLPVARNRRTLNDVTVSSNDQSMPDEMDQKPVERVKPLKEPQLVHSNANKKIIFPKFSANKMDNIFAFTLNVRNVDPSSIELQKGTDTVSCRFTNIGNGFFPCYYIFFLRFPNANITEVQHEEWDNNIILQVVLDHGLIDCYYAGTNENDLVQYSIMEDITDKINKFGKEIEDDSLCIAVSKNAIKQERKSSHLSIEIKTKDEIESDEGIDSALEGELKTDQSMQEDENPDEINTRTVEDDTKVAKENVKKVDQETAHEGKKSKKNQRRKNKKRSLSESCCDHLKVTINNDNPKPESGNEANSFEGTGSSSEATSKQRKARSVSESCPARDNNGVESDSVDNLSALIQFNHKYKGILKRSSLQRSISECSSIDEHYYLGTSVDGSSVAESVDHTNGELSESCRKTVRFNDAIKTKLFRSNTSILGQKKKNAKKNESKRRALTRRLSEGESTDNEDKDHQTTNEAPGSVVQRDTEHDSGISLDSDAAHPIEINADTEVQNQHQNDSTKPIEINRKVEKKFIASKNNNCNVKAQFIKSKRNDSSDIEFKSDMIFDIEM

101.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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