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AAE3_01767

Gene
AAE3_01767
Protein
Ribonuclease ageritin
Organism
Agrocybe aegerita
Length
136 amino acids
Function
Ribonuclease which cleaves 28S RNA in eukaryotic ribosomes and shows antitumor activity (PubMed:28232091, PubMed:30262416). Its toxic action on eukaryotic cells is the result of cleavage of a single phosphodiester bond in the 28S subunit of ribosomes (PubMed:28232091, PubMed:30262416). Exerts cytotoxicity and induces apoptosis towards rat glial cells and human glioma cells, and also displays some activity towards human neurolastoma cell lines (PubMed:28232091).
Similarity
Belongs to the ribotoxin-like family.
Mass
14.933 kDa
Sequence
MAETVQYYNSYSDASIASCAFVDSGKDKIDKTKLVTYTSRLAASPAYQKVVGVGLKTAAGSIVPYVRLDMDNTGKGIHFNATKLSDSSAKLAAVLKTTVSMTEAQRTQLYMEYIKGIENRSAQFIWDWWRTGVAPT