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PHYPADRAFT_141055

Gene
PHYPADRAFT_141055
Protein
tRNA (guanine(37)-N1)-methyltransferase
Organism
Physcomitrella patens subsp. patens
Length
480 amino acids
Function
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
Mass
53.604 kDa
Sequence
MAAPGCSPVGIDKSAFVVRLPRVALRIPKQKSHRVASLLSKYLLDMPRVKHIVEDPQDPSMRLLLFSEAIAQPDLEGVSEEKILAVKEIVPLDVVQHEVVLDYSYWPVEHILKEILPAGCEVPSSFETIGHIAHLNLREDLLTYKKIIAEVILDKNPKLKTVVNKVGTITNEFRVPEFEILAGEPSLVTEIKQHGATFRLDYGMVYWNSRLEGEHKRLFAQFKPGQVIVDMFAGIGPFAIPAAQQGCAVYANDLNPTSVKFLKLNSDINKVGESIKAFNLDAREFMRKLVTEEEGCVGEIASSTLIAENSLNGTRIPSSKENSSSLTEGSDMPSSKKPEERKAKKAKVSEVVKMKISDVKPWEHFDHVVMNLPASALEFLDVLNGLLCKGRWKGTMPRVHCYCFMRSNETNADIVKKAETYLGGSIADPDVYVVRDVAPNKASLAFTAVVSWFISRSFIWSLYFFCLIQAHLVLDSIEHR