Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity).

single

430 amino acids

HCDGVNLTCEACQEPGGLVVPPTDAPVSSTTPYVEDTPEPPLHNFYCSKLLDLVFLLDGSYRLSEAEFEVLKAFVVGTMERLHISQKRIRVAVVEYHDGSHAYLELRARKRPSELRRIASQIKYVGSQLASTSEVLKYTLFQIFGKIDRPEASRVILLLTASQEPQRMARYFTRYLQGFKKKKVILIPVGIGPHANLKQIRLIEKQAPENKAFLLSGVDELEQRRDEIINYLCDLAPEAPAPSKPPQVAHITVSPGISGVSSPGPKRKSLVLDVVFVLEASDEVGEANFNKSKEFLEEVIQRMDVSPAGTHIAVLQYSYTVNVEYTFKEAQSKEDVLRHVREIRYQGGNRTNTGQALQYLSEHSFSPSQGDREQAPNLVYMVTGNPASDEIRRLPGDIQVVPIGVGSRANLQELERISRPITPIFIQDFE

48.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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