Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.

Belongs to the RtcB family.

476 amino acids

MHVPGTFYVNDALKGLLFEELQQAVVRGDHGGFLPAVKQLANVAALPGIVKRSIALPDVHSGYGFAIGNVAAFDMDNPEAVVSPGGVGFDINCGVRLLRTNLTEAEVGPVREQLAQALFDHIPVGVGSQGIIPTTAKDMESALELGMDWSLREGYAWAEDKEHCEEYGRMLNADPRYVSSRAKKRGLPQMGTLGAGNHYAEVQVVDEVYDAVAARRMGIDTPGQVVVMIHSGSRGLGHQVATDALVAMERAMARDGIITNDRQLACARINSEEGQAYLKAMSCAANYAWVNRSSMTFLARQAFAKIFKSTPDDLDMHVVYDVSHNIAKVEQHCVDGQHRRLLVHRKGSTRAFPPHHPLIPADYQLIGQPVLVGGTMGTSSYVLTGTEQGFTETFGSTCHGAGRARSRNNSRNKLDYQDVLDNLKAKGIAIRVASPKLVMEEAPESYKDVSEVVDTCHQAGISKKAVKLRPIAVIKG

51.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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