tRNA nucleotidyltransferase involved in the synthesis of the tRNA CCA terminus. In contrast to what is usually observed in eukaryotes for which one enzyme synthesizes the whole tRNA CCA terminus, in S.pombe, cca1 specifically adds two cytidine residues to a tRNA substrate lacking this sequence while cca2 specifically adds the terminal adenosine residue thereby completing the CCA sequence.

Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

500 amino acids

MASSSSILELNETEKELSDIFLNVSKKIGQMDRKEPEVRFAGGWVRDKLLRIESHDIDVAIDCMSGFEFAQHLQSYLAQQHPDWETKVIKIDANPLKSKHLETATARIMGMDIDIVNLRHHDYTNSNSSNKLVFGTPLEDALRRDATINALFYNLKSKTVEDFTGKGLVDLSNKIIRTPLVADETFGDDPLRAVRCIRFATKYDFNIHEETIKGLKNPELHERLRSSISRERIGVEVDKMLKHCNTNRALKIIHSLGMFACIFGPLEIHTKKLQSKNIESLSLIPYAIDLFGYLQKKDVSIKNLSSSSKYIFWLAIATLPWYNWSILEKSKIKILPPILIRDSLKYSKPIMSQVENFFVHYPLIMSKINVLEKEGKLTRLGCGRLVRELGPHWRDIIDWAFFMNTLISNSDIQRLNKDEEVTWFHVLVKHIEEYGMEEAYNIQPIINGNEITRILGIRPGPHLRKMLDDSIEWRIQNPESTKEDYIAIMLEKGTSAVVDS

57.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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