Required for the splicing of precursor tRNA molecules containing introns. The ligation activity requires three enzymatic activities: phosphorylation of the 5' terminus of the 3' half-tRNA in the presence of ATP, opening of the 2'3'-cyclic phosphodiester bond of the 5' half-tRNA leaving a 2'-phosphomonoester and ligation of the two tRNA halves in an ATP-dependent reaction.

Belongs to the TRL1 family.

787 amino acids

MTRDQRVCIFGEKKSTVRSVTFKAPKSNYDLTSWRIWEQAFRLNVSNSKKCFDTISGHRITLPTNARGLFTGYDYESKRHRIVIRGYDKFFNIDEVPITTWDALSQHTKGPYELTVKENGCIIFIAALPDGQIIVSSKHSLGIVEGQSVSHANVGERWLEKHLQSVGRTKQELAHELLRRDMTAVAELCDDEFEEHILPYTGNSRGLYLHGLNRNCPQFITASSCEVAEFAEQWGFMKVSSFFMDSIHELKAFLENASKDGKWNNRAIEGFVIRCHSDHSSLEQQSSNDFFFKYKFPEPYGMFRQWREVTKMLISGKKPSYTKYKKVTAEYITFCDKKFKEDEDAKRLYMSNKGIISLRDEFLVLSKLDLMHLSVSNDNDCGKEFTLLVPIATIGCGKTTVAKILEKLFGWPVVQNDNLPSGKGGPKRFAKAIIEEFRNGHSVVFADRNNHISNMRSTLQTDILALIDGVRFVALPFKHTPEVPEFVQNRVLQRGDRHQSIKVSEGVDKVKAIMNTFYKQYKPFDPAGNKHDANYDDIIELDPLIGSLENARRIVNYFKKNIPELIPNDPSDDDYAAALNYAVNEYVPTYRKTFGNDSKKIKNKITAEGITGSSTCFKKAPRYFGVLLDRKTVESSLVQVLTIANLQWQEAFSRYTLQDSFHITMIHESQKPVNSRIWEQYLQHMHDKNTTKMGNISFRITHLVWDDRVICFRVTMNENSVWYGKTCNPQLHITLGTSSSDVKAFESNFLLKKLRWQGDEVDSTDGNVRYLTVLPKIIIEGMLEPVY

90.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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