S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of a 2'-O-methylguanosine in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

531 amino acids

MISIFKILSSPKPATTTTNIINPINIINGIRYFSSNQEDYPLFKKPVFNGKVLRGGRKVFKNDLIYSKKESHYNNNNNSNNNSNNNNNNNNSNNRNNNNFSNNRNNNNNRNNNNNNSNRNNNNSNDNNFRNNNNNNRRTEYYKNDFDSSKYISNKPEIRIFDLHEQAVYGINPVWVALSSGNRTFNALYVCGTLLPKLKELGIDIKNIENSKREYISDFDHNYGRETNQIEDENQDEQYSNQHDEQEQNEYEEEQEEEKVQEEEEDNNNNNNIKKTTFNRYNDRKNLVALKEIVKNSFKLKIPVRSVNKGTLDSFSKGRPHQGIILDASPLTLLNIDFLEKFDINERVNKRMNGGGGGGGGGGGNKINNDKYPLWLVLDELWDPQNVGAIIRNCSFFNIDGVVISNKNSSPITPAASKSSSGACESFVINRTESIEGFLKSSQRNGWNVVGTSLDDLNENQPCLDINQIKLDQPTILILGNEGFGLKPSVLEICNKTIKIVGGNYKIDSLNVSVTSGILIHTLLSSGTLPK

60.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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