Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP. Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Shows very low activity on dGTP or dUTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP.

Belongs to the HAM1 NTPase family.

181 amino acids

MYFITSNEGKFREVREMASKYGIEIEWLKMEYIEPQGSSLEEIARLSAEMLAEKVEGEFVIEDSGLFVEALKGFPGPYSSYVFKTIGNEGILKLMEGVENRKAYFMAVVAYFDGKEVRTFTGKVEGEISREMRGTQGFGYDPIFLYGNKTFAEMATEEKNQVSHRRKAFEEFFRWLKENKI

21 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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