Protein expression services for gli3 | Zinc finger protein GLI3
Description
Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and may play a role in limb development. May bind to the minimal GLI-consensus sequence 5'-GGGTGGTC-3' (By similarity). Has an essential role in the early embryonic patterning of mesoderm and neuroectoderm.
Family
Belongs to the GLI C2H2-type zinc-finger protein family.
Species
Xenopus laevis
Length
1569 amino acids
Sequence
MEAQSRSTTASEKKKVENSIVKGHSRTEVSEKAVASSTTSNEDESPGQTYHRERRNAIAMQPQGGQGLGKISEEPSTSSEERASLIKKELHGSITHLPEPSVPYRGTVFAMDPRNGYIDPHYRSDLDLFPAFHPPVPIDARHHEGRYHYEPTPIPPLHVPTALASSPTYPDLPFFRISPHRNPASASDSPFSPPHPYISPYMDYIRSLHSSPSLSMISAARGLSPTDVPHAGISPAEYYHQMALLAGQRSPYADIFPSPATAGAGANALHMEYLHAMESSRFSSPRLSARPSRKRTLSISPLSDHSFDLQTMIRNSPNSLVTILNNSRSSSSASGSYGHLAASAISPALNFAYQPTPVSLQQMHQQIMSRQHSIGSAFGHSPPLLHPAPTFPSQRTIPGIPSVLNPVQVSIGPSEAAQQNKPTSESAVSSTGDLLHNKRSKVKPEEDHPSPGAVCIQDQPDGMTLVKEEGVKDESKQEAEVVYETNCHWEGCSREFDTQEQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDIHPRPPPPREPGSHSQSRSPGQQTQGIHGEHKDLSNTTSKHEECLQVRSVKTEKPMSSQPSPGGKSSCSRQQSPISNYTNSGIELNLNSGGSIGDFSALDETPIMDSTISTATTGLGLHGRRVMTGTKWMEQIKVEKMKQVNGMLPRLNPVPPHRAPTLPPITGNGVQLNSNISLGGLAPVLPNRNDLSSMDITVLNMLNRRDSNTSTISSAYMSSRRSSGISPCFSSRRSSEASQFEGRVQNLSVAGSYDPISTDASRRSSETSQCDGLPTLLSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKTRMALLGDSRDCRLSPLPSVNVPRRCSDGGVGSYGRRHLLPNELQVNGMRRASDPVKMVSDNVSNTRVVRFNSLNNVIPPDVPPPMERRNLSLQNYTRNVYSPCPPSISENVALEAMIMEAEGNFDDEDLLPDDMVQYLNSRNQRLYETIETDALQNNAGERNGNNFEQSHVTSNVINEQFHSSEQTDLIENKNDLPIQWNEVSSGSAEYSPSRLKYGQRFPTQQNQPFGLYNNMMVQQQNVPKSGLSQQRGYQHHTQNNPQAPQQNLDLYNNSNVWSGQLGRGNQYIDDIERSSLGHSATGSLCNSAARGQKLTTNGLPMNTGQQNFGPSTHYSVQSANRAEVVQNENIINQEFMQQMTAEHLIYGMHLLGVTRSNQTTSGQNGNTTDGTRSFLSTTQNGGEQQPTLAKNFQSFVNSSGNSRQNLHRNNLPYLQEQIYDTNQHIFKVNSIKMEMQSHPQQHCANAQNFSGQLYDQTATYPQQIMKSGSEPGMEANCLLQESNNTNSSKLLSPGANHVTSTVDNIDNSLAGVQIAFAAIIDDGDHASLISGVLSPSIIQNLSRNSSRLTTPRASLTFPAIPVSTSNMAIGDMSSLLTSLAEESKFLAIMQ
Mass
172.6 kDa
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)Safety
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Protein synthesis service
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