Force generating protein of eukaryotic cilia and flagella. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.

Belongs to the dynein heavy chain family.

4466 amino acids

MGDVVDARLDFISEYILKSYKLKPDKWTKCINVEENKILMLEFLEKADNPQLVFTVNPAGLITPSYEFPSALKNTKAIYFIKKGREPVGKDNIKTNLVYGDLSYTPLEQLSALVDEVLVPLLANPRNHEQWPVVVSQDVLRHVHNLKSSVYVVAGQVKGKTLLPLPVGSEKVETAAGSEEKDDSYDRSLVHAIESVIIDWTHQIRDVLKRDSAQPLLEGLNPGPMVEINFWKAKCENLDCIFQQLRDPKVRKMKELLERTQSSYLPSFNNIERDVEAALTEAQDINIHLKPLVYQIESMDELEFSDLTPRLAPILHTVCLIWSNSDYYNTAPRVIVLLQEICNLLIDLCRTFLDPSEIFKLEPEESLEKVRGALTVLKNWRELYDEHRAKLKDYFKDGKEVKEWEFASPLVFTRMDNFIRRIETIQSLFETNVEFSKLEKTEMGSMKGRMLSQQVEKIHEEFQECAKVFTERPYDGLDPTCQEFLEDYEEFEKKVFDLDRRLGSILCQGFDDCCGLEAAFKMLDCYGPLLDRPVIRNDFECKYPIVLMLYDQELDQSKEIYDEHMRVEEANGNAPLNKNMPDVAGQLKWSAQLRDRISKPMGSLKHMEHPTGVRRILESEDAKVIFQKYEEMLNLLNKYEQKVFENWTKGVDEVCKTNLDQSLITRDDASKLIMVNFDPKLVSVLREVKYLQIRGEETIPESAASIYEKHETLRKYVANLDLTVAWYNKVRKTVLEVEFPLIEGQLADLDTRLRQAEADLNWTSDSVWEYIQETRDQVRDLEKRVQQTKDNVDRIKKIMAEWTKQPLFERKELKKESLLALDDRQDRLKKRYAEITTAGEKIHSLMKENLDLFKAEASSDIWKAYVDYVDDMVIDGFFNCIHCTLTYLLENTDPRHCAAPLFEARLELQVPDMIFNPSLDYGIADGFYDLVEMLISDTYKMASLVNRLAEHNGQEHYQADLEGMDDLSDVRNDLMDRVQTIMTKAQEYRNSFDNYAYLYVDDRKEFMRQFLLYNHVLTTEEIEAHAEDGVPECPPTLDQFKEQVDTYEKIYSEADEIEPEQVFDAWFRVDSKPFKAALLNIIKKWSFMFKQHLIDHVTNSLSELQEFIKVGNSGLTKTVEDGDYNGLVDCMGHLMAVKERQAATDEMFEPIKQTIELLKTYDQEMSEEVHTQLQELPEQWNNTKKIAITIKQQVAPLQANEVAIIRRKCTSFDVRQHEFRERFRKEAPFIFLFDGPYQCLDKCHSEIYEMEEHMAKLQESAGLFEVNMPDYKQLKACRREVRLLKGLWDLIMVVRTSIEDWKTTPWLEINVEQMEMDCKKFAKDIRSLDKEMRAWDAYNGLDATVKNMLTSLRAVSELQNPAIRERHWQQLMAATKVKFTMDKETTLSDLLALNLHNFEDEVRNIVDKAVKEMGMEKVLKELNTTWSSMDFDYEPHSRTGISLLKSNEELIETLEDNQVQLQNLMTSKHIAHFLEEVSGWQKKLSTTDSVITIWFEVQRTWSHLESIFIGSEDIRNQLPEDSKRFDGIDTDFKELAAEMEKTPNVVEATNKARLFDRLEAIQGSLVVCEKALAEYLETKRLAFPRFYFVSSADLLDILSQGNNPTQVQRHLSKLFDNMAKLKFKQDDEGNDTKLALGMYSKEGEYVDFDKECECTGQVEVWLNRVMDTMRSTVRSQFADAVVSYEEKPREQWLYDYPAQVALATTQVWWTTEVNISFARLEEGHENSMKDYNKKQILQLNTLIGLLIGKLTKGDRQKIMTICTIDVHARDVVAMMVLKKVDSAQAFQWLSQLRHRWADDDKHCYANICDAQFKYSYEYLGNTPRLVITPLTDRCYITLTQSLHLVMSGAPAGPAGTGKTETTKDLGRALGIMVYVFNCSEQMDYKSCGNIYKGLAQTGAWGCFDEFNRISVEVLSVVAVQVKCVQDAIRDKKERFNFMGEEISLIPSVGIFITMNPGYAGRTELPENLKALFRPCAMVVPDFELICEIMLVAEGFLEARLLARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDPQRPEDQVLMRALRDFNVPKIVSDDTPVFMGLIGDLFPALDVPRRRDLDFEKVVKQSTLDLKLQAEDSFVLKVVQLEELLAVRHSVFVIGNAGTGKSQVLKVLNKTYSNMKRKPVFIDLNPKAVTNDELFGIINPATREWKDGLFSVIMRDMSNITHDGPKWIVLDGDIDPMWIESLNTVMDDNKVLTLASNERIPLTPSMRLLFEISHLKTATPATVSRAGILYINPSDLGWNPIVTSWIDTREVQSERANLTILFDKYLPTLLDTLRIRFKKIIPIPEQSMVQMLCYLLECLLTPENTPADCPKELYELYFVFASIWAFGGSMFQDQLVDYRVEFSKWWITEFKTIKFPNQGTVFDYYIDQESKKFLPWSEKVPTFELDPEIPMQAVLVHTNETTRVRFFMDLLMERGRPVMLVGNAGLGKSVLVGDKLSNLGEDSMVANVPFNYYTTSEMLQRVLEKPLEKKAGRNYGPPGTKKLVYFIDDMNMPEVDTYGTVQPHTLIRQHMDYKHWYDRAKLTLKEIHKCQYVSCMNPTSGSFTINSRLQRHFCVFALSFPGQDALSTIYNSILSQHLANIAVSNALQKLSPTVVSATLDLHKKVAQSFLPTAIKFHYVFNLRDLSNVFQGLLYSGSDLLKSPIDFARLWMHECQRVYGDKMINDQDIEAFEKLVFEYAKKFFEDVDEEALKAKPNIHCHFATGIGDPKYMPCATWPELNKILVEALDTYNEINAVMNLVLFEDAMQHVCRINRILESPRGNALLVGVGGSGKQSLARLASYISSLEVFQITLRKGYGIPDLKLDLATVCMKAGLKNIGTVFLMTDAQVSDEKFLVLINDLLASGEIPDLFADDEVENIIGGVRNEVKGMGLQDTRENCWKFFIDRLRRQLKTVLCFSPVGTTLRVRSRKFPAVVNCTSIDWFHEWPQEALVSVSKRFLDEVELLKGDIKNSIAEFMAYVHVSVNESSKQYLTNERRYNYTTPKSFLEQIKLYESLLAMKSKELTAKMERLENGLTKLQSTAQQVDDLKAKLASQEVELAQKNEDADKLIQVVGVETEKVSKEKATVDDEEKKVAIINEEVSKKAKDCSEDLAKAEPALLAAQEALNTLNKNNLTELKSFGSPPSAVLKVAAAVMVLLAPNGKIPKDRSWKAAKVVMNKVDAFLDSLINYDEENIHENCQKAIKEYLNDPEFEPEYIKGKSLAAGGLCSWVVNIVKFYNVYCDVEPKRIALQKANDELKAAQDKLALIKAKIAELDANLAELTAQFEKATSDKLKCQQEAEATSRTITLANRLVGGLASENVRWGEAVANFKIQEKTLPGDVLLITAFVSYIGCFTKNYRVDLQDRMWLPFLKSQKDPIPITEGLDVLSMLTDDADIAVWNNEGLPSDRMSTENATILSNCQRWPLMIDPQLQGIKWIKQKYGDELRVIRIGQRGYLDTIENAISSGDTVLIENMEESIDPVLDPVLGRNTIKKGRYIKIGDKEVEYNPEFRLILQTKLANPHYKPEMQAQTTLINFTVTRDGLEDQLLANVVAQERPDLEKLKSDLTKQQNDFKIILKELEDNLLSRLSSAEGNFLGDTALVENLETTKRTAAEISVKVEEAKVTEVKINEARELYRPAAARASLLYFILNDLNKINPIYQFSLKAFNTVFSLSIARAEPCEDVKERVVNLIDCITYSVFIYTTRGLFEADKLIFTTQVAFQVLLMKKEIAQNELDFLLRFPIQVGLTSPVDFLTNSAWGAIKSLSAMEDFRNLDRDIEGSAKRWKKFVESECPEKEKFPQEWKNKSALQKLCMMRALRADRMSYAVRNFIEEKLGSKYVEGRQVEFAKSYEETDPATPVFFILSPGVDPLKDVEALGKKLGFTFDNNNFHNVSLGQGQEIVAEQCMDLAAKEGHWVILQNIHLVAKWLSTLEKKLEQYSIGSHESYRVYMSAEPAGSPESHIIPQGILESSIKITNEPPTGMFANLHKALYNFNQDTLEMCAREAEFKVILFALCYFHAVVCERQKFGPQGWNRSYPFNTGDLTISVNVLYNYLEANSKVPWQDLRYLFGEIMYGGHITDDWDRRLCRTYLEEYMAPEMLDGDLYLAPGFPVPPNSDYKGYHQYIDEILPPESPYLYGLHPNAEIGFLTTESDNLFKVVLELQPRDAGGGGGGGSSREEKIKSLLDEIVEKLPEEFNMMEIMGKVEDRTPYVVVAFQECERMNTLTSEIRRSLKELDLGLKGELTITPDMEDLSNALFLDQIPASWVKRAYPSLFGLSAWYADLLQRIKELEQWTADFALPNVVWLGGFFNPQSFLTAIMQSMARKNEWPLDKMCLQCDVTKKNKEDFSSAPREGSYVHGLFMEGARWDTQTNMIADARLKELAPNMPVIFIKAIPVDKQDTRNIYECPVYKTKQRGPTFVWTFNLKSKEKAAKWTLAGVALLLQV

511.8 kDa

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