Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane.

1098 amino acids

MRTSLQAVALWGQKAPPHSITAIMITDDQRMIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTCLARARDFSKQPYIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEGWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQDSLLVVSVAGELKVWDLSSSINSIQEKQDVYEKESKFLESLNCQTIRFCTYTERLLLVVFSKCWKVYDYCDFSLLLTEVSRNGQFFAGGEVIAAHRILIWTEDGHSYIYQLLNSGLSKSIYPADGRVLKETIYPHLLCSTSVQENKNRPFVMGYMNERKEPFYKVLFSGEVSGRITLWHIPDVPVSKFDGSPREIPVTATWTLQDNFDKHDTVSQSIIDYFSGLKDGAGTAVVTSSEYIPSLDKLICGCEDGTIIITQALNAAKARLLEGGSLVKDSSPHKVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGAQIICCVCSDHSVALLHLEGRSCLLRARKHLFPVKMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARIILNCCDDSQLVKSVFPIASETLKHKSIEQRSSSPYQLGPLPCPGLQVESSCKVIDAKFCPRPFNVLPVKTKWSNVGFHILLFDLENLVELLLPTPLSDVDSSSSFYGGEVLRRAKSTVEKKTLTLRKSKTACGPLSAEALAKPITESPAQGDNTIKFSAENDGIKRQKKMKISKKMQPKPSRKVDASLTIDTAKLFLSCLLPWGVDDLDYLCIKHLNILKLQGPISLGFASNEDNFSLMLPGWDLCNTEMIKDYSGVNLFSRKVLDLSDKYTATLPNQVGIPRGLENNCDSLQESDTIVYLLSRLFLVNKLVNMPLELACRVGSSFRMECVHNKVRSAGNDILNMSSFYSCLRNGKNESHVPEADLSLLKLISCWRDQSVQVTEAIQAVLWAEVQQHMKSLGKIPVNSQPVSMAENGNCEMKQMLPKLEWTEELELQCIRNTLPLQTPVSPVKHDSNLNSANIQDMEDMPDRCVLEESESPGEPRHHSWIAKVCPCKVS

123 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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