Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (By similarity). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).

Belongs to the shaker potassium channel beta subunit family.

401 amino acids

MQVSIACTEHNLKSRNGEERLISKQNAAAPNVVNAARAKFRTVAIIARSLGTFTPQHHISLKESTAKQTGMKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAEQLMTIAYESGVNLFDTAEVYAAGKAEVILGNILKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLRASLQRLQLEYVDVVFANRPDNNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNLIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRAALKCYQWLKEKIISEEGRKQQTKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSNPEQLIENLGAIQVLPKMTSHIVNEIDNILGNKPYSKKDYRS

44.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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