Binds actin and actin filament bundles in a Ca(2+)/calmodulin-insensitive manner, but is unable to sever, cap, and nucleate actin filament formation in vitro. Does not protect individual filaments from severing by VLN3 (AC O81645).

Belongs to the villin/gelsolin family.

909 amino acids

MSRLSKDIDSAFQGVGTKSGLEIWCVYNKQLISIPKSSFGKFHSGNAYLVLRTFLRKIESPQYDIHYWLGIDANEVDSILASDKALDLDAALGCCTVQYREVQGQETEKFLSYFKPCIIPVEGKYSPKTGIAGETYQVTLLRCKGDHVVRVKEVPFLRSSLNHDDVFILDTASKVFLFAGCNSSTQEKAKAMEVVEYIKDNKHDGRCEVATIEDGKFSGDSDAGEFWSFFGGYAPIPKLSSSTTQEQTQTPCAELFWIDTKGNLHPTGTSSLDKDMLEKNKCYMLDCHSEVFVWMGRNTSLTERKTSISSSEEFLRKEGRSTTTSLVLLTEGLENARFRSFFNKWPQTVESSLYNEGREKVAALFKQKGYDVEELPDEEDDPLYTNCRDNLKVWRVDGDDVSLLSIPDQTKLFTGDCYLVQYKYTYKERTEHLLYVWIGCESIQQDRADAITNASAIVGTTKGESVLCHIYQGNEPSRFFPMFQSLVVFKGGLSRRYKVLLAEKEKIGEEYNENKASLFRVVGTSPRNMQAIQVNLVATSLNSSYSYILQYGASAFTWIGKLSSDSDHEVLDRMLYFLDTSCQPIYIREGNETDTFWNLLGGKSEYPKEKEMRKQIEEPHLFTCSCSSDVLKVKEIYNFVQDDLTTEDVFLLDCQSEVYVWIGSNSNIKSKEEALTLGLKFLEMDILEEGLTMRTPVYVVTEGHEPPFFTRFFEWVPEKANMHGNSFERKLASLKGKKTSTKRSSGSQYRSQSKDNASRDLQSRSVSSNGSERGVSPCSSEKLLSLSSAEDMTNSSNSTPVVKKLFSESLLVDPNDGVARQESSSKSDISKQKPRVGINSDLSSLESLAYSYEQLRVDSQKPVTDIDATRREAYLTEKEFEERFGMAKSEFYALPKWKQNKLKISLHLF

103 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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