Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

347 amino acids

MLDSFMTQLEIVGNRSKCVNMLLWSIFGFGVLKATTLILRIMACFVDLFVLPPVNYSKYGSKNGNYCVITGASDGIGKEFAFQMAKRGFNLILISRTLSKLETLQKEISTKYNVKVEVLAIDVAKDSEDNYSAIKELCGKFPITALINNVGQSHSIPVPFLETDEDEMRRIITINNTATLMITQIIAPMIIKTTKESSKKTRGLILTMGSFGGLIPTPLLATYSGSKAFLQSWSSSLAGELKEHNVDVELIISYLVTSSMSKIRKTSMMIPNPKTFVASTLRNIGRRCGAQERYATITPYWSHALYQLAIVEAVGVYSHLVNYINYVFHKSIRIRALKKAARDAKKQ

38.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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