Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome. Deubiquitinates ZNF304, hence may prevent ZNF304 degradation by the proteasome, leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs).

Belongs to the peptidase C19 family. USP28 subfamily.

1047 amino acids

MTAELQAASGGPGGLEADCQVLNKMKEITGIQDADFLHAALKAAKGNLMEALIVLTEERDQEPVQNTAAAEPSSWEGSAVGKEPPQGGAAFDPEKKGDVHSAVAYGQLESPKAHAAERPQEVHSPEHKNRSKRKRCEVWGENSKQSDWKRVGDWPVGMKNIGNTCWFSAVIQSLFQLPQFRRLVLSYSFPPNVLESCRTRTGKRNIAFMQELQCLFALMLGTRRKFVDPSAALELLRDAFKSTEEQQQDVSEFTHKLLDWLEDAFQLAVNVRSPGDKSENPMVQLFYGTFLTEGVHEGNTFSKIETFGQYPLQVNGYRNLNECLEGAMVEGEMDEETATQSVKYVQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHTKLEFPQTIFMDRYLYCSKELIQTKREEMKKLKEKMLVLQQKLERYMKYGSGPARFPLPDMLQYVLEFITTKPAGAVSSACVSSTEDSQMMDRQSQGESLILGTPSQPDSMLDGKDGKPEDEAVLLANSSPQQQLNAPLQPSEPPAEMSDCPAPHVVSEEEMNLVTTCLQRWRNEIEQDVRDLKESIARVSLSIDEMYSDPHLQQVPYHLHAVLVHEGQANAGHYWAFIYDQPRKSWLKYNDISVTESSWEELERDSFGGLRNASAYCLMYISDKVSHVVAGEGDGSEVGQFQKEVEALPPELRRYIQEDNWRLEQEAEEWEEEQSCKIPSTASESQELSPESGLDPPAAHEQSLRSLSSEHAMIAKEQTAKAIANAANVYEKNGVEAALCEAFHEEYSRLYLLSKETPTPQNDARLQHVLVYFLQNDAPQQIVERTLLEQFADKNLSYDERSISIMKVARDKLKEIGPDEVNMEEYKKWHEDYSLFRKVSVYLLTGLELYQNRKYKESLTYLIYAYQSNTTLLKKGANRGVNESLITLYRRKCLLKLNEVASSLFVSCEEAHVAEGISILNELIIPCMHLINNFDISREDMDAIEVMRNRWCSYLGREDMDASLQIRLGELLPRLLDGSTEVVVLKEPPKIRPNSPYDLCSRFAAVMESIHDASTVTVK

118.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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