Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels (By similarity).

Belongs to the peptidase C19 family. USP10 subfamily.

785 amino acids

MAVNGAQYIFGEFSPDEFNQFFVTPRCSVELPPYNETVSCGIKSTNEEYQRIEFGVNEVIETESSVLNNTDYSISSTLNPQAPEFILSCAPAQKTPDETNYNSIDCQFSDPTLTLDSGSNAENDGLSGGLGQRERKKKKKRPPGYYSYLEDVSDGVAPTEALVNGHANSSGLNSIGTEDTELTGDIPSLATPRTCNSPDNSVDFVHEAVSDDSVSSALDNTRTAGQPEVCRVTNSEQFCIPSETGRDSPLRTAVVQPYAGTDTTESLGVTNGQTLESSGEDTAANGVELHTVESTDSDQAKPEEASPTTEATATVAGSVPVNQPAKSWASLFHNSKPSASTSVVYVETKYTPPATSTLVPEKQVEVKEGPVPVSEDPVAIKIAELLENVKLVHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKSIPMYSKSQRPCTSTPMIDSFVRLMNEFTNMPVPPKAKQALGDKIVRDIRPGAAFEPTYIYRLLTVIKSSLSEKGRQEDAEEYLGFILNGLHEEMLTLKKLLSPHNEKLSVSNGPEVQTVREEEEQDEQGEGSEDEWEQVGPRNKSSVTRQADFVQTPITDIFGGHIRSVVYQQSSKESATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISRRVTLEELPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELLSPGVKSKIFKGQRTYRLFAVVYHHGNSATGDHYTTDVFQIGLNGWLRIDDQAVKVINQYQVVKPSAERTAYLLYYRRVDLL

86.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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