Involved in the assembly of an N-linked disaccharide that decorates the S-layer glycoprotein and flagellins (PubMed:18978056). AglK initiates N-linked glycosylation through the formation of alpha-linked dolichyl monophosphate N-acetylglucosamine. It catalyzes the transfer of GlcNAc from the donor substrate UDP-GlcNAc to dolichyl phosphate C55 (Dol-P) to yield Dol-P-GlcNAc (PubMed:23624439). AglK reaction proceeds with retention of stereochemistry (PubMed:23624439). The reaction is specific for UDP-GlcNAc. AglK shows a stronger preference for short dolichol (C55-60 Dol-P) substrates compared with the longer (C85-105 Dol-P) (PubMed:23624439).

Belongs to the glycosyltransferase 2 family.

251 amino acids

MADKLIYLIIPAYNEEKMIKNVVNNLQNHNYDNIIIVDDGSKDNTYKIMKELEEESKQNNNNNNNNNNNKVIAIKHEQNKGVGGATITGLKKAYELGADIAVTFDADGQHAPDDIAKVIQPIINDSKEYVVGSRIKNPKEFKNMPLTKKVGNLGLSFITFLLGGYYVTDSQSGLRAFSKSALKVLSEQLRAKRYETCSEALIIAKKNKLNIGEVPIKTIYTEYSMARGTNVMIGFKIFYRLLMLKMGKVLD

28.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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