Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell attachment and cell migration. Acts downstream of EGFR, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11 (By similarity).

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.

823 amino acids

MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSFIGVHQQIEAEMIKVTKTELEKLKSSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHVLHNQYVLALKGAQLHQNQYYDTTLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTAESLQVMLKTLAEELIQTQQMLVNKEEAVLELEKRIEESSKTCEKKSDIVLLLSQKQTLEELKQSVQQLRCTEAKFTAQKELLEQKVQENEGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSALGSSTFSDTIPISEKPLAEQDWYHGAIPRIEAQDLLKQQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQFVDNLYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWVLNHEDVTLGELLGKGNFGEVYKGILKDKTAVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPIYIIMELVPGGDFLSFLRKKKDEIKLKQLVKFSLDAASGMSYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQATEQVERGYRISAPQHCPEDIFKIMMKCWDYKPENRPKFSELQKELTVIKKKVTQ

94.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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