Essential glycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates alpha-tubulin by adding a single glycine chain to generate monoglycine side chains, but is not involved in elongation step to generate polyglycine side chains on alpha-tubulin. Has the ability to both mono- and polyglycylate non-tubulin proteins such as up (Troponin T). Required for early steps of spermatogenesis.

756 amino acids

MTTQNTTPAGFTGNRNRYYNPVSKIQSLIHNLDAELVQLCKQCSVQKPLTSLNNSTSLGSHFSNFGALGGGSGSKTMGGSSSMGSNNFSPDSIGNLLARVRASTPLPRTVTSSPTAPEAQKRQMRNVYRTRVIDAYRNRRIFTVYGNYHTVRRALMRRGWLEKLPASRHAKLQSMSEDALLEHARRGNDYEAVVISKMINHFPAFFIWQGKGQRDLCAEVRPFRNRVRRSQFLDFSTKVGLVGCAEQERWYREDGVCGMSYPRFYRLGGNNLEERMAFIEDYQQTQARSLLLYVREHQPAELISENGTIFSTTLDFALGKVKKMVRHAEHYSLDDARIKPPTPAEIVENQTFMVQSTDVLKSNAKFKVSEKVMAEYARLAGLYLDQIESLRPDYRWDGSRNLWILKPGYQSRGIGIVIRSSLDDILQWTSNNQNKKYIVQKYIERPLLIYRTKFDIRQYMLLTITDTKVSIWTYRDCYLRFSSQEFTMDDLRESIHLTNNSVQKRYKNKTNRDSRLPKNNMWSLDQFKNYLRIMGAPDGSWSKTYNGFKQNLVAVVMASLDETELLQNAFELYGCDFMLDEHYNPILIEINSTPDLSPSTEITARICPMVLKDCIRVVVDLPKNPTAATGLFELAFEVNYSINKGADGKPLELNGKQMTLFENMPRMRNSPRTRLLRKILNNVKTSTTKKVEKVVEAPAKNVKNPTAKITKKKKLSASAGSSTAASAQPSTQNLTTKLILNPATRENLALQYTAPK

86.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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