Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.

Belongs to the tryptophan 2,3-dioxygenase family.

369 amino acids

MKPMSYWDYIKVEELLALQGGANGDETQVGNDEALFIVVHQVYELWFKLILRELTFARDLLRQDTVPGHQIALGVRSLRRAIAVFEQANQHFRVMETMTARDFLDFRERLMPASGFQSAQLREIEILLGLEDNERIAVCQGGSFKDALKLPNGALSSAAYRVEAREAHGQSLKHCLYAWLSRIPIDGSNEPAAVKRFLRDYIGSVRAESQRRLQTAIDRQLAPAEVERLRARYQADDVGAETFLLAEEDPQADAMTREKRRAVRAAMLFVESYRELPQLAWPRELLESILELEQSMLIWRQRHARMVERIIGRRVGTGGSSGVDYLDQTALRYRVFTDLWTVRSLLLRKSSVPPIRQGASYAFAEEALV

42.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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