Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.

693 amino acids

MIQSAAPSCRRWWALGFAAVALWVDSTSGWTTQRPPMAGLRRFQSSAWYMSSSSTEKPTTSGTINGGGGKQKAASQPKKTAGIVYDAQKIRNFSIIAHIDHGKSTLADRLLETTQTVAQRDMEAQLLDNMDLERERGITIKLQAARVLYQARDGEMYCLNLIDTPGHVDFSYEVSRSLAACEGALLVVDASQGIEAQTLANVYLALENDLEIIPILNKIDLPAADPERVAEEIEATIGLDCSGIVHASAKTGIGIDDILERIVQMVPPPPAATGGPFRALIFDSYYDAYRGVIVFFRVMDGEVSQGDKVRFLASDAEHDVTEVGIMQPNQVPVDCLHAGEVGYLWGNIKDVLDARVGDTIVLAKEYKESASKGKSPPIEALPGYADSVPMVYCGLFPVDADQYESLRDALGKLRLNDAALSYEPESSGAMGFGFRCGFLGLLHMEIVQERLQREYDIDLIVTAPSVVYKVKKEHQEEFFIDTPAKMPDLGRNDVALEPYVRMEVLTPSEYNGAIIELGQERRGDLIDIKFLTPTRSTIVYELPLAEVITDFFDQLKSRTKGYASMEYSLIDYRASDLVRLDVKINYEMAPPLACVVHRDKAQSIGRRLCASLKDLIPRQMFKIPIQACIGVKVIASESISPMRKDVLAKCYGGDISRKKKLLQKQAKGKKRMKSIGKVNVPQEAFMAVLKLNE

76.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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