Transcription factor that regulates the gene cluster that mediates the biosynthesis of monakolin K, also known as lovastatin, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:18578535, PubMed:19693441, PubMed:19968298). Monakolin K biosynthesis is performed in two stages (PubMed:19693441). The first stage is catalyzed by the nonaketide synthase mokA, which belongs to type I polyketide synthases and catalyzes the iterative nine-step formation of the polyketide (PubMed:18578535, PubMed:19693441). This PKS stage is completed by the action of dehydrogenase mokE, which catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the mokA-mediated biosynthesis of the nonaketide chain and leads to dihydromonacolin L (PubMed:19693441). Covalently bound dihydromonacolin L is released from mokA by the mokD esterase (By similarity). Conversion of dihydromonacolin L into monacolin L and then monacolin J is subsequently performed with the participation of molecular oxygen and P450 monoogygenase mokC (PubMed:19693441). Finally, mokF performs the conversion of monacoline J to monacoline K through the addition of the side-chain diketide moiety (2R)-2-methylbutanoate produced by the diketide synthase mokB (PubMed:19693441). HMG-CoA reductase mokG may act as a down-regulator of monacolin K production (PubMed:18578535).

455 amino acids

MALSPVQDPPSHTDKTMPRRAFRRSCDRCHAQKIKCIGSEGAVARASCQRCQQAGLRCVYSERCPKRKLPKPNPAESSPASSTAGLHTSSSDSSPPVPSDGLPLDLPGPDSSGVSLQFLDPSADCDWPWSSIGVDETVVNNCLDLSHGHGHGDLSCQLELPMPDLPSPFEFSAEKSPSPSVSGSIAGAVSAQRELFDGLSTVSQELEAILLAVAVEWPKQEIWTYPIGTFFNASRRLLVYLQQQSNTRSDQGMLNECLRTKNLFMAVHCYMLIVKIFTSLSELLLSQIRHSQAGQLTPLEGHQFEPPPSSSRDRSSVDTMPIFNPNLHIGGLFSYLNPFMHALSSACTTLRVGVQLLRENESALGIPPAQGVAASVSMGKEEWADGEDVASAVTTADEDLRQPASRILSMVWSDEVGDQKAKSADAAGPRSRTLAVLRRCNREIFSLARQHNLAS

49.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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