Synthetic multivulva class B (synMuvB) protein (PubMed:11463372, PubMed:17075059). SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription (PubMed:11463372, PubMed:17075059). May also negatively regulate vulval development in association with other SynMuv class B proteins such as lin-15A (PubMed:11463372). Can stimulate E2F-dependent transcription (PubMed:17075059). Plays a role in negatively regulating the progression through the G1 phase of the cell cycle during postembryonic development, most likely by acting as a transcriptional repressor in association with the cell cycle regulatory factor efl-1 and the transcriptional repressor lin-35, but may also act as a positive regulator of cell cycle entry (PubMed:12062054). Involved in the regulation of intestinal cell division during postembryonic development, most likely in complex with efl-1 and lin-35 (PubMed:17466069). Promotes germ cell programmed cell death, probably together with efl-1, by positively regulating the expression of the apoptosis proteins ced-3 and ced-4 (PubMed:17881492, PubMed:24752899). In particular, positively regulates the expression of ced-4 in response to starvation (PubMed:24752899). Its role in programmed cell death may be in conjunction with cell cycle regulatory factor efl-1 and the synthetic multivulva class B proteins lin-35, lin-37 and lin-52, and is independent of the ced-1, ced-8 and ced-9 pathways (PubMed:17237514).

Belongs to the E2F/DP family.

598 amino acids

MNPTNYDPRIGQPAQSRPQVSLSMGRRIVQMPTGLPRSYQDESHNEPVGWDEPSGVGGSSGAGGQQSDKPTGLRHFSTKVCEKVKEKGLTNYNEVADELVADYFQNNLIKQIDVVKQEYDMKNIRRRVYDALNVLLAMNIITKSKKDIRWIGLPASASQEISRLEEEKSRREASISSKKQALEEMVLQIVSYKNLVERNRKNEHKNGRPENDTVLHLPFLIINTDKEANVECSVSSDKSEFLFSFDKKFEIHDDFEILKKLNLACSLETTNPTAEEVKTAKSFLPTLHQHYVDEIIANRKKVEAEKEEKRKQQQLIADQMSMNLSQAQYVEPTSSLAQMSYSSRFNRQLQEHLINDGSEDRSAAAGIMERDYDMDKNVNQGSASRGPMYNTYSPQKIRAQVNTPLQVPPVTKRYYVQKTQGPMKHDMTPVVRTVNRPYSTVPPDRRLSTGATSVNSGPVKYYVPQGHQPMHQPVGQRYRVRPQQPQMSHMGQPHQVQQRVVYPAGSISGHQLQPGQRIVTQRIVAPGGPHPPGTIVRKVIRKIVVNNPKQSPAQQVIQKKMMEQDMCTFERKTEQPMTSAQAAALIQHPQPEEYDYFQ

67.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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