Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (By similarity).

Belongs to the bZIP family. CNC subfamily.

374 amino acids

MSPCPPQQSRNRVTQLPIPEPGEMELTWQEIMSITELQGLNAPSEPSFEPPAPVPYPGPPPPPSYCPCSIHSEPGFPLPAPPYELPAPTSHVPDPPYSYGSNMTVPVSKPLTLSGLLSDPLPDPLALLDIGLSAGPSKPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVEMYPVEYPYSLMPNSLTHPNYALPPAETPLALEPSSGPVRAKPTARGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLARYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLGSERERLLRARGEADRTLEVMRQQLTDLYRDIFQHLRDEAGNSYSPEDYALHQAADGAIFLVPRGTKMEATD

41.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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