General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress.

Belongs to the TFIIB family.

519 amino acids

MSGAKQCPDCGSSDIVEDAHYSQDQVVCADCGCILSEGLITTTAAEESHLQAVRFADSTGENDSMTVSKLRGIVRVRNICRVLRLPDGFSDTAVSYYEQAYKHPLYHSVSIEKKEIIVGCCVYITCRQHQWPITMATICSLVYAKKELFASIFLSIVQVLKLDVPSVSLQNLVMSHCRSFKLFKDSCEVPSHYAEKLDTVSERTVQTVELAYETWLVTGRHPIPIITAAAYISWQSLLPARRLSCSLSRFCKLSDVDLPPPSAIRLRELQGTLIKLSVYLPWLKVLSLNKKTVVQHLGDLLRHRVFLLRKALAVTEAELSRGTLADTEAQLSRGTLADTEAQLSRGTLADTEAQLSRGTLADTEAQLSRGTLADTEAQLSRGTLADTEAQLSRGTLADTEAQLSRGTLADTEAQLSRGTLADTVAQLSRGTLADTEAQLSRGTKALSSNDQPNSTFVFLPPCVSNPRKRSRSIPFPRGHLDITGDEDISDSEIEQYLRTPAEMKEFEQALNRDDELPNA

57.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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