Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (By similarity).

Belongs to the ENY2 family.

123 amino acids

MASTTTTILPKDHIKLRSTIHQKLIESGEKERLKVLLKSKLVEGGWRDEVKIACREYIKNNQNENFKIEDLIALITPIAKKKVPPQVKADLIKRIRKFLGPNIQNHHHHHIHIQSNTPNSPHH

14.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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