Toxic when overexpressed in E.coli, leading to long filamentous cells. The toxic effect is neutralized by non-cognate antitoxin HipB (PubMed:28430938). Does not seem to inhibit DNA, RNA or protein synthesis, and unlike paralogous toxin HipA its toxic activity is not counteracted by overexpression of GltX (PubMed:28430938). Binds DNA (PubMed:28430938). Might be a protein kinase (By similarity).

Belongs to the HipA Ser/Thr kinase family.

443 amino acids

MSELTDLLLQGPRSAPELRQRLAISQATFSRLVAREDRVIRFGKARATRYALLRPYRGIERIPVWRVDDTGKAHKFADIRLCWPQGSCLVTGADGDEQWFDGLPWYLTDLRPQGFLGRAWGRKLAAQLNLTDDIRLWQEEDVLYALTVFNGEYTGGWLVGEGNYQRWITAQHPAEIPLDQKLTHYEQLASDALAGEIVGSSAGGEQPKFTYYAQTPSGNKHVLVKFTVPQQTAVSQRWGDLLIAESIAAQILRDGGIHAIESTVLVTSNRQVFLEAERFDCKGNDGRLPIVSLEAVQSEFISSPGSWPQAMRRLCEQQLVTHQSVAQTEVIWAFGRLIANSDMHAGNLSFYLSEPPFALTPVYDMLPMVYAPNSAGMLRDAAIEVKFDLNVSKSAWLTAIPLAQQFWQTVARDPRISEAFRHIAQEMPEKIRQIEEKVARMGG

49.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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