Description
Poxvirus TMP kinase is able to phosphorylate dTMP, dUMP and also dGMP from any purine and pyrimidine nucleoside triphosphate. The large substrate specificity is explained by the presence of a canal connecting the edge of the dimer interface to the TMP base binding pocket, canal not found in the human homolog (By similarity).
Family
Belongs to the thymidylate kinase family.
Species
Variola virus (isolate Human/India/Ind3/1967)
Sequence
MSRGALIVFEGLDKSGKTTQCMNIMESIPTNTIKYLNFPQRSTVTGKMIDDYLTRKKTYNDHIVNLLFCANRWEFASFIQEQLEQGITLIVDRYAFSGVAYATAKGASMTLSKSYESGLPKPDLVIFLESGSKEINRNVGEEIYEDVAFQQKVLQEYKKMIEEGEDIHWQIISSEFEEDVKKELIKNIVIEAIHTVTGPVGQLWM
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service