Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3).

Belongs to the TTC39 family.

617 amino acids

MALVGSRVELDADEDIFEDALETISRSPSDMATSGFHFVPCDTKRTSRQLGAPAVGRAEGSSAKVDLKSGLEECAAALNLFLSNRFKDALELLRPWAKESMYHALGYSTIVVLQAVMTFEQQDIQNGISAMKDALQTCQKYRKKCTVVESFSSLLSRGSLEQLSEEEMHAEICYAECLLQKAALTFVQDENMINFIKGGLKIRTSYQIYKECLSILHVIQKNKEEQHFFYEFEGGVKLGTGAFNLMLSLLPARIIRLLEFIGFSGNRDLGLLQLREGASGSSMRSPLCCLTILAFHTYISLILGTGEVNVAEAESLLAPFLQQFPNGSLILFYHARIELLKGNAEKAQETFRKCISVQEEWKQFHHLCYWELMWIYIYQQNWMQAYYYSDLLCKESKWSKATYVFLKAAILSMLPEEEVAVTKENVVSLFRQVDGLKQRIAGKSLPTEKFAVRKARRYSPSSGVPGKLVLPALEMMYVWNGFSIVGKRKDLSENLLVTVEKAEEALQNQNFTDYSVDDECLVKLLKGCCLKNLQRPLQAELCFNHVLESEKLLKYDHYLVPFTLFELAFLYKSQGEIDKAIKVLETARNNYKDYSLESRLHFRIQAALHLWKKPSSD

70.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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