Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response. Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria.

232 amino acids

MGIGKSKMDPCHLSVPWGKSQSVDTSQSHHMSDSKQSEEISLHGDAVCSSTAEMPAEEQEGVEERPEEDTEEEVFLKFVILHAEEDTGEALRVQSLLENDFGIKPGIIFAEMPCGRQHLQNLDDAVNGSAWTILLLTENFLRDTWCKFQFYSSLMNSVNRQHKYNSVIPMRPLNNPLPRERTPFALRTINALEEESRGFPTQVERIFQESVYRIQQAIWKETRNTVQRQSVA

26.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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