Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (By similarity).

Belongs to the synembryn family.

539 amino acids

MDPGTLLDKLESGDQELVQKALAEYNQENSQCFFFNAEQREERKKLGELVIKFLNRDLQPSCQMACLETIRILSRDKHALSPFTGRSAIQTLAQYAGLDYSEEMEMPSIPDGESAVEALKGLCNIIYNSVEAQEVAKELRLVCGLARRLKLYNETRSSHESKFFDLRLLFLLTALSVDMRKQLAQELRGVSLLTDALESTLALKWSDIYEVVTDRLAPPLGKEETERVMEILKTLFNITFDISRREVDEEDAALYRHLAAILRHCLLRQCDGEDRTEEFHGHTVNLLVNLPLMCLDVLLTPKVEQGSVEYMGMNMDTVEVLIQFLDRRLDRGHKLRETLTPVLNLLTESSRVHRETRKFLRAKVLPPLRDVKNRPEVGNTLRNKLVRLMTHVDTDVKHCAAEFLFVLCKENVSRFVKYTGYGNAAGLLAARGLLAGGRGEGRYSEDEDTDTEEYREAKPNINPVTGRVEEKQPNPMDGMTEEQKEYEAMKLVNMFDKLSREQIIQPMGVTSDGRLEPLDEAAQKMLQRQESSDLESDSD

61.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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