Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (By similarity).

Belongs to the synembryn family.

539 amino acids

MELRTVVATVESGEQDAVLKVLQIYNQEKSQCFTFDDEEREERKKMAQLLIKFLERELQPSCQVTCLESIRILSRDKYCLEPFTTEEGLKTLSRHAGIDYSEELIREVPDLEVILESLKCLCNIVFSSPRAQELTAEARLVVGLTKRIKLYNERSLPHEVKFFDLRLLFLLTALRVDIRQQLAQELRGISLMTDTLELTLGVKWMDPYEVATEEGLLPPLPRQETERAMEILKVLFNITFDSSKREVDEEDAALYRHLGALLRHCLMISADGEDRTEEFHSHTVNLLGNLPLKCLDVLLTPKVRPGSLEYMGVNMDAVNILLDFLERRLDRGHKLKESLTPVLNLLTESARVHRQTRKFLKAKVLPPLRDVKNRPEVGNSLRNKLVRLMTHIDTDVKHCAAEFLFVLCKESVSRFVKYTGYGNAAGLLAARGLMAGGREEGEYSEDEDTDTEEYKEAKPNINPVTGRVEEKLPNPMEGMTEEQKEYEAMKLVNMFDKLSREQVIQPMGITPSGNLAPMENAIRDMADERSSSDSDLGLD

61.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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