Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Also able to activate the G(s)-alpha in synaptic signaling network. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i) alpha protein goa-1 and gpa-16 independently of G-protein coupled receptors (By similarity).

Belongs to the synembryn family.

567 amino acids

MPGDQLTEETIQRVFLNATSAKIEEFFSKWNFSNANSTKFGMSEAERNLLGDEISAKIDNDDLASILLETVRLISRERQGLESLLNENLCDTILKLAGITPVVGYPRSVHALMEAQKCLVNTMFHSAKMRERFYMNLVNGDQIQRFLSEFEDSRRENSNIQWIREMNPTQAAEVWYFYHRIAFIATAMDKGFQRHWADQSTTVSNILCAAEVCLQKASDDVANLDLLRANEAMKTFFNVFCHFHGDVPGLDEKNTHLACRILRDVICSGIPNDDVIQSAIHALSVPPLPMDLSVLLSDPNFPIVPLPETISEEERVHPRDYYVNMTLTEAILAALDKQLIKAVDLLNSVPFNQVSPEGNTLVDLSGPYFQALARLCVESKYARRYCRIRVLPPLVADEVKKRPEEHDSLRGRIVRVMMLPSTTKEVASEFLFIICKRSVSRMIKYVGFGHSAGHLANFGLLGQINQPKHASDSEDSETEDYNAVKDNVNPVTGAMYPPDHGSAMDGMSDAQKEFEAMKLVDAMNKLMDQGLVKPGTIGDDGKVREVSHVLELLKDAPEPDTMDSDSD

63.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.

Make ric-8 using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)

Order Here