Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).

585 amino acids

MGSLKDELLKGIWHAFTALDLDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEGPVSNQGYMPYLNKFILEKVQDNFDKIEFNRMCWTLCVKKNLTKNPLFITEEDAFKIWVIFNFLSEDKYPLIIVPEEIEYLLKKLTEAMGVSWQQEQFENYKINFDDSKDGLSAWELIELVGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMIKKGHRRKNWTERWFVLKPHIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLIKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKLLAEQEELERQMKELQIANENKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVIKEQALQEALEQLQQLELERKQALEQYEGVKKKLEMAAKMTKSWKDKVAHHEGLIRLIEPGSKNAHLITNWGPAAFTQAELEERQKSWKEKKTTE

68.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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