Multi-functional protein that contributes to the endocytic process, but also to events that occur at the neck during budding and/or cytokinesis. Plays a role as an endocytic adapters with membrane-tubulation activity that associates with transmembrane cargo proteins and initiates the formation of endocytic sites. Contributes to the stabilization of the nascent clathrin-coated pit. Plays also a role in late endocytosis by mediating vesiculation. Involved in the regulation of cell cycle-dependent dynamics of the septin cytoskeleton by promoting septin turnover in different cell cycle stages. May act through the RHO2 signaling pathway to repolarize cortical actin patches in profilin-deficient cells.

Belongs to the SYP1 family.

870 amino acids

MTEQRTKYADSILTTKSPYEATETIRIRLSQVKLLNKDFYLLFKELANLKRNYAQQLRKIIAENEDITKILNAQMIESNVLTPQEMSAFRFNSLGELRNVWDTVIEELKSDLKSSTEYYNTLDQQVVRELKESVENNTSWRESKDLHSKLSKNAASIEHYSKNNENSSHLEEARRQWDQQSPYLFELFETIDYNRLDTLKNCMLRFQTSFSDYLLNTTKECETVMTKFLAFEPQSEIDRFAKDASQYNFQLSSSSKEVVPNNASPASATGARPVSVSNGAANTEREKKSPQKDKRKSAFGNIGHRLASASSSLTHNDLMNNEFSDSTNNSSLKSKKSSHTLRSKVGSIFGRNKTKNKRQQQSSSNSHIQASITETPNNSSTRVSSTATSSIYQKQRRPTYSSSKSNNWTPGEASDTPPLPPHATPKNVDAPVTADTPPAQTFTPSEVPPSTPQQSSPPTAKEPDSSNLPKTVPISISQPPLQPQSKTKPLPVEPASPSISLPTATVDNQPSGQVDSRPLHIRAPALPPSRKQNFIHNRDSQLYDSLPNHGSGATPTSSSLSSIPQERPVSTLSSQITGELRELNPQATGSSTSLVGQSLFQHSSLDTSQFGLNASIAEVLNASFKDGMLQNSQLIGEIALNYLPNSVMNSPLPIGINLRINNGAKFEKVILNQAFIERVAPEEFKVNPSFIDSRTLGAIKYSIKEPIAPIVIHPVWRFESHQASVVLTVKMSPSLPDEISQIVIEDLVVFVNIDGANATSALSKPQGSFSKEKKRITWRFKEPVVLTRNGEGQRLIARFITDGLAHESAKGVITKFTISETDNVALPHSGAGSGITLTCQELDENNPFGGEWLDVNTKRTLTTGNYHGLA

96.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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