Adenylyltransferase involved in the biosynthesis of several sulfur compounds. Is required for the 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2-thiouridine (m(5)s(2)U or s(2)T). This modification allows thermal stabilization of tRNAs in thermophilic microorganisms, and is essential for cell growth at high temperatures. TtuC catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein TtuB. Is also involved in the biosynthesis of thiamine, molybdenum cofactor (Moco) and probably tungsten cofactor (Wco), by adenylating the sulfur carriers ThiS and MoaD (PubMed:19037260). Is required for the conjugation of TtuB to target proteins (PubMed:22467871).

Belongs to the HesA/MoeB/ThiF family.

271 amino acids

MRWTKEELDRYHRQMILPQVGPEGQERLKRASVVVVGAGGLGVPVLQYLVAAGVGRVGVVEMDRVEVSNLHRQVLYTTEDVGEPKALVAQKRLQALNPLVRVEAYPVRLTSENALEILRPYDLVVDASDNFPTRYLVNDAAVLLGKPLVFGAIYQFDGQVAVFHHPTLHGEMGPCYRCLFPKPPPPGAVPSCAEAGVFGVLPAVVGSLMAAEALKVLLGIGKPLAGHLLLYDALEASFRKLTVRRNPRCPVCGDEPTQRELVDYEAFCGLR

29.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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