GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.

415 amino acids

MLRAAGNLSKSMMKSQRRFLNLQEFQSKEILEKHGCSVQNFVVASNRKEAEEKWMSFGDHEYVVKAQILAGGRGKGKFINGTKGIGGVFITKEKDAALEAIDEMIGKRLVTKQTTSEGVRVDKVMIAEGVDIKRETYLAVLMDRESNGPVVVASPDGGMDIEAVAEKTPERIFKTPIDIQMGMTEGQSLKIAKDLQFEGKLIGVAAQEIKRLYDLFIAVDATQVEINPLVETADGRVFCVDAKMNFDDSAAYRQKEIFAYETFEEHDPREVDAHQFNLNYIGMDGNIACLVNGAGLAMATMDLIKLHGGEPANFLDVGGAVTEDAVFNAVRIITSDPRVKCVLINIFGGIVNCATIANGVVSAVNKIGLNVPMVVRLEGTNVDAAKQIMKKSGLKILTANNLDEAAAKAVSSLPK

45.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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