Major secreted subtilisin-like serine endopeptidase. Preferentially cleaves substrates containing hydrophobic residues at P4, positively charged residues at P3, small or flexible residues at P2, and large, bulky residues at P1. Mediates the degradation of collagen, the major structural protein in the mammalian host. Degrades the nonhelical regions of collagen that function in the cross-linking of the helical components (PubMed:25944934). May function as virulence factor involved in epidermal wing necrosis observed in white nose syndrome (WNS) in bats (By similarity).

Belongs to the peptidase S8 family.

400 amino acids

MKFSQSLIALAACFLPLIAAAPEEAQHAKIRSPGAQDIILDSYIVVFNKGVNDADIESEFASVSHILSKRRPAHKGVGHKYNITGFKGYQIETDTGSIGEIAASPLVAWIERDGKVQANALETRSGATWGLGRISHKATGSNSYVYDSSAGSGSTVYVVDSGIYIEHSEFEGRAKWGANYISGSPDTDENGHGTHCAGTIAGATYGVASKANLVAVKVLDGDGSGSNSGVIAGINFVGQNGKDGKSVLSMSLGGSYSAALNSAVESTISNGVTVVVAAGNDGADASNYSPASAKNAITVGAVDSTDTRADFSNYGSVLDVFAPGVDVKSAWIGSKSASNTISGTSMATPHVAGLAAYLIGLGGLSSPAAVASKIASIGIQGSVKDPKGSVNLIAYNGNGA

40.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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