Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.

Belongs to the SLX4 family.

714 amino acids

MSPEGEESHAEDNLYFHNTQMQSIHEETLAEESHAQAIQRSISRLSSFKHEDTDSESPIPVQKVIRQIKKTNTNTNTTKTKKRKLKVSKPRKNMSSSESVRQMYGSRKNGEQQGSIDGFLMSRFGEVDGCNESDRSSKLISQGEWESLSKFHEESNEKDKLLRKKIQRYYSEPQEELGEGCGMLTQASADPETKMTKEELESLYDLDSSTVFNQTTISAIGDMSEPTQVSEPCVVILSQTKVQSEASTQEDGADASVQEIKSTVPAQELFSTPEFVPAPLEQPVNKEMCSDQSIVVLEENVQSTQADDSDIVELISDSDPEPEEVSTKVQVLRSIYDSSGPVNDKQPSVASETVESDSTPIVSPVKTPQGTRMHVVQVASSNPSSPIKIVEENTEQQEEVFTDVESIYSTARTSFGTPKHTSPVILLESSDTDCDDNDNDVEPLSSMPMVKTVPKKRMRTTVLQVSAALKVQNYTDEKNNIKLRKIGDDIPVEVPTKDVEYEEIPDSQESVGGEGDNSVSIIEITREVHNNDYTGDESTDLFQVGLNKQDTCEDTSSPVVQIGGVENDILDSSLIEPVPEPESVPVPEEVQEQPQPTAIDKHTATQLREKFQLWGLKPVRGKEKMVEILQGISNFILPEHELLAVADKQELQSCIFRKLDAVIREGRAMYDRILSFEPIRLEELQSMLQSQDHYLELDVLRLYCDSSGITTTNA

79.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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