Protein expression services for scap | Sterol regulatory element-binding protein cleavage-activating protein
Description
Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the scap/srebf complex from the ER upon low cholesterol. Low sterol concentrations trigger a conformational change in the SSC domain of scap, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of srebf in the Golgi, release of the transcription factor fragment of srebf from the membrane, its import into the nucleus and up-regulation of ldlr, and the mevalonate pathway (By similarity).
Family
Belongs to the WD repeat SCAP family.
Species
Xenopus laevis
Length
1311 amino acids
Sequence
MPLIDKLRERISRAFYSHGLLCASYPIPIIILTALCILASCYPLLKLPLPGTGPVEYVTSVKDYSPPPLEPNPEDHSDQPDWYVGLPVAFIQQVLVKAVVSPWDKDFLAVDVFRSPLSRVFPLVEEIRNHVLRDKSQEKSLEDVCLQVTDLLPGLKKFRDKLPEHGCLLLSPANFWQNSQEQFSSDPDLIRTIHQHEPKTLQTSATLKDLLFGVPGKQSGVSLYNRKRIVSYTVTIALRRYNATFLDSLRSRLKRQHPSTNSSAASQHIVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDLVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLRNESWFIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRMELADLNKRIPAEACIPPPKPGAKRYDRQPTLRPATPHTITLQSLRNLRLPKRLRLVYFFARTRLAQRIIMAGTVVWIGILVYTDPAGLRNYLTVHVTEQSPLGGAVMPPIPVPVLSASNPHGPLSAVFPTGSSQLLENQSQRDSKEVIDSLSSRIWEESHPEDKSKERAAKIEDKAHTQVTWGAEDEETWRKLSFRHWPTLFSYYNITLAKKYISILPMIPVTLYLTPQEVSDARHPQEAQHSHPYLQREGKPDEAWARVEAKGAEKPTENQTPADVTLYKVAALGLASGIFLVLFFFLLYRLLCPKNYGQNGVSHGRRKKGDLPCDDYGYSPPETEIVPLVLRGHHMDIECLASDKMLLVSCCLAGQIRVWDAQSGDCLTIIPKPSLRRESSGVFEYQDNWEPTPECKYNPEESLENGYQLKRRTLHPPLFSDQPDLTSLIDTNFSEQPANEESGARQRLSCIKQESPPIGYDFSSLVQKVYEEHEVSSFGSFPLVLSPAPYGQCQLSSGRRSQTPAGCVDGSCARRKSSTEETTGYCNGSSSPAPSWTDSFESSVWSLGLQGNLIVVGRSNGNLEVWDAIEGSLRCSNCDGQSGITSLVFLNHRVVVARLNGSMDFYCLDSQKSSNQLQFRGAPNRSNVPSSPLYSTDDVIGCQRTHTVACAHRKPITALKAAAGRLVTGSQDHTVRIYRLEDACCLFTLQGHSGGITAIYIDETMVLASGGQDGAICLWDVLTGSRVSHMFGHRGDVTSLLCTASCVISSGLDDVISIWDRSTAIKLYSIQQDLGCGSSLGLISDNLLVTGGLGCVSFWDVGYGDLLQTVYLGKCEDSQPARHILVLDNSAIVCDFGSELSLVYVPSVLEKLD
Mass
145.4 kDa
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service
Make scap using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)
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