Endonuclease which shows activity towards both DNA and RNA substrates (PubMed:14508492, PubMed:26808625). Has a role in translation regulation throught its association with the with the RNA-induced silencing complex (RISC) (PubMed:14508492, PubMed:26808625). Plays a role in spermatogenesis probably by negatively regulating piwi expression in the germline (PubMed:26808625). Together with piwi, might be involved in transposon repression in the germline (PubMed:26808625).

926 amino acids

MATAANTATAAGAAKDAPPAPTKSLSGIVKQVLSGDTVVIRATKGAPPPEKQITFSHVLAPKLARRPGAGGDETKDEPWAWESREFLRKKLIGVEVTFTFDKPANSNREYGFVWIGKDKETGENVVESIVREGLVSVRREGRPTAEQQTLIELEDQARAAGRGKWSPTASAADKVRNIKWSHENPAHLVDIYGGNPVKAIIEHVRDGSTVRAFLLPDFHYITLMISGIRCPGVKLDADGKPDLSVKVPFADEARYYVETRLLQRDVEIRLESVNNSNFIGTILYPKGNIAESLLREGLAKCVDWSMAVMKTGTDKLRAAERFAKEKRLRQWQDYQAKTPAFNSKEKDFSGTVVEVFNGDAINVRLSNGQVKKVFFSSIRPPRDQRAVVGTDGEEIVKAPPRGKNYRPLYEIPHMFDAREFLRKKLINKKVQCNLDYISPPRENFPEKYCYTVSIGGQNVAEAMVAKGLATCVRYRQDDDQRSSAYDQLIAAEQQAIKGLKGLHAKKDNATLRVNDLTVDHSRIKVQYLPSWQRALRTEAIVEFVASGSRLRIFVPKDSCLVTFLLAGISCPRSSRPALNGVPAQEGEPFGDEALTFTRERVLQRDVSVHIDTTDKAGSSVIGWLWTDSGANLSVALVEEGLAEVHFSAEKSEYYRQLKIAEDRAKAAKKNIWTNYVEEVPKEKTVTEEEKEDKVVAERKVNYENVIVTEITETLTFFAQSVESGSKLESLMSKLHADFQSNPPIAGSYTPKRGDLVAAQFTLDNQWYRAKVERVQGSNATVLYIDYGNKETLPTNRLAALPPAFSSEKPYATEYALALVALPTDNEDKEEALRAFSEDVLNHKVQLNVELKVTGSPNLATLRDPTTKVDFGKQLVAEGLVLAEQRGERKLKELVDQYKAAQEAARVAHLAIWKYGDITQDDAPEFR

103.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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