Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Has been found in complex 'B' and 'C' as well (By similarity).

Belongs to the SF3B4 family.

359 amino acids

MASNLPQERNHEACLLIRDLDPMVTESLLMELFIQAAPVVKVFIPKDKLTQQHSGRAYVEFQSSSDAEYALKVMKFVRLFNKEIKIKKENKDKVDIGANLFIGNLDADVDERILHDTFSRFGTIIFTPKVMRDENGVSKGFAFINFDSFEASDAAIEAMNSQFLCNKPISVTYARKKDSNERHGSSAERIIAASRNTGYLNQQQQQQSSSTSSTSTISTSTPQQQQQQQSQPLPPPIVTAGGIIHQQQIQQQQQLQQQQQQQLQLQQLQLQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHHPHHQHPIPHPHPLPHQLRPHPHPHHPPPPPFNPMLMQFNPMMMPFGGMPPPPPHK

41.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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