Proposed to be involved in endosomal maturation implicating in part vps-33.2. May play a role in epithelial polarization through stabilization of apical membrane protein content. May play a role in transcriptional regulation (By similarity). Plays a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes. Essential for vesicular trafficking during spermatogenesis; required during spermiogenesis or sperm activation for the morphogenesis of specialized Golgi-derived fibrous body-membranous organelle (FB-MO) complexes. Required for the processing of internalized proteins in oocytes and coelomocytes.

Belongs to the SPE39 family.

522 amino acids

MALRRKFTFELPEDSYWNESDSNSSGLFDDLQSKQLQARAAVDNLFGGDETPKPYVRPQNPTPTPTNVPLQIDGRAAAVSDKANIRITDTSPRASGKIVDDFLNMKFAENVNVAPVIQTAPSVVSEASASSLPSEAQRLDLDYNRLRQEHRKLKDQHEVLRHERFQPLTIEASIKRMLQGHTVTLDYYRSLRDKTQLLKQAVATYDNNTIFKIVIFLERTLKENIFCKIMDGQKSACRVYTRHLQITGEWDKMNKFLRSIGQYQHASVIEFEATRKYKRNPDKRVPLLRTMLHGSFSIPEMKFEARQMEALMRNYEIQLQMEKMDAGDKGEHFRKFPKTSSLIGLPALSSLYYSAMYHYDDSPTSAASLPSVQTLIRFNDRLATQTIVSALTRLSRWPDIDKLLQPKTITMTFSAAKSVFKGKKSTSKWGVSINNHNLLTIVKRSHPSPPTDFIYRILKGESDAQERLRLALLFDVPEMVIECLTQKGDRLSLASYAKSLKTNSVESFKAVAALNNPSIKWK

59.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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