Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity).

Belongs to the major facilitator superfamily.

532 amino acids

MARGEGAEQFSSGLLPTAKSVTQNEIKMVKLPKQQERKRALTVWSKVCFAIGGAPYQITGTALGFFLQIFLLDVAQLNPLNASVILFVGRAWDAVTDPTVGFLVSRTPWTRHGRMMPWILVSTIPAVLCYFLIWVVPPIEQGKMMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQRERDSATAYRMTVEVFGTVVGTAIQGQIVGMANTPCKNNTSPNNSSNDLIQSNNSHIPLKSNIFDERCAYMIASAVISLIYVVCAAVLFFGVREQDVQGELKAQKRVSFQKGLRLVMGHGPYVKLVLAFLFTSLAFMLLEGNFAVFIKYTLGFREDFQNILLVIMVSATVSIPMWQWFLCRFGKKTAVYIGITWAVPFMILVVSVNSSLIVSYIVSIAAGVSVGAAFLLPWSMLPDVVDDFKLQNPTSQGHEAIFYSFYVFFTKFASGVSLGVSTLALSFAGYETGVCVQSDSVNLTLKLLVSAAPVSLIALGLLIFMTYPIDEERREYNNKQLQLLLRNEEEEDEMEVLKPDITA

59.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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