Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.

Belongs to the methyltransferase superfamily. HEN1 family.

393 amino acids

MEENNLQCSSVVDGNFEEVPRETAIQFKPPLYRQRYQFVKNLVDQHEPKKVADLGCGDTSLLRLLKVNPCIELLVGVDINEDKLRWRGDSLAPFMGDFLKPRDLNLTIILYHGSVVERDSRLLGFDLITCIELIEHLDSGDLARFPEVVFGYLSPSMIVISTPNSEFNPLFPSVTLRDSDHKFEWTRMEFQTWALYVANRYDYSVEFTGVGEPPAGAENVGYCTQIGIFQKNGGRATEACVSEQHDQHVYKAVFTTSYPSLQQERFFKLVLVNEVSQQVESLRVSHLPRRKEQDGEQGDKPKDIGGSKAPVPCFGPVFTEVEKAKIENSPKPFCVGDKFFVPLQRLLAYPRLNRLCANEEMMRSVIADSIPLSSDGSAVVTDLCNYFDEQFEF

44.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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