Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity).

Belongs to the interleukin-1 receptor family.

409 amino acids

MAGVCDRVPNFLSPSEDQALGPALGSAVALNCTAWVFSRPQCPQPSVQWLKDGLALGNGSHFSLHQDFWVSDNFSEIVSSVLVFNLTKAEDYGTFTCSAWNVSSHSFTLWRAGPAGHVAAVLASLLVLVVLLLVALLYVKCRLNVLLWYQDTYGEVEMNDGKLYDAYVSYSDRPEDRKFVNFILKPQLERRRGYKLFLEDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLRRPWCSQSFREGLCRLLELTRRPIFITFEGQRREPIHPALRLLRQHRHLVTLLLWKPGSVTPSSDFWKELQLALPRKVQYRPVEGDPQTRLQDDKDPMLIVRGRAAQGRAMESELDPDPEGDLGVRGPVFGEPPTPLHESKVSIGEGHASEMDVSDLGSRNYSARTDFYCLVSEDDV

46.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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